The service of University of Gondar library system dates back to more than half a century during the establishment of the Gondar Public Health and Training Centre. The library system was established in 1954 to serve students of the Public Health and Training centre in the then Gondar College of Medical Science (GCMS).

In 1978, when GCMS was established the GCMS library was also redesigned in organization, manpower, and in reference books including journals and other supporting documents. This time the library was intended to serve medical doctors, nurses, environmental health students. Beyond this it is intended to support the above programs to meet their objectives in serving as a source of information and reference as well as researchers. However, the service was given in buildings built for other purposes than for library service which does not fit for purpose. The year 1999 was a remarkable date where the GCMS library was transformed into a new building built for library, the now GCMS library.